Acute digoxin ingestions occurred in only 17 (6%) patients with a median age of 43 years (range 7 days to 87 years). The median age of this group was 73 years (range 32 to 93 years). There were 31 (11%) cases of acute-on-chronic poisoning. The median age of these patients was 78 years (range 17 to 97 years). The majority of these patients, 238 of 286 (83%), presented with chronic digoxin poisoning. Of these, 286 patients (134 males and 152 females) received Digibind. Data on Digibind use in BC and patient outcomes have been collected from 1991 to 2002.įrom 1991 to 2002, DPIC was consulted on 348 cases of digitalis glycoside toxicity. This is replaced free of charge by DPIC if the antidote is administered according to guidelines developed by DPIC and the health care treatment facilities. In this model, which is unique in Canada, hospitals purchase an initial stock of Digibind.
When digoxin-specific Fab antibody fragments (Digibind) became available in Canada in 1991 as an antidote for digitalis glycoside poisoning, a centralized distribution model was implemented by the BC Drug and Poison Information Centre (DPIC). Digoxin toxicity can result from inappropriate dosing, worsening of renal function, drug interactions, and intentional or iatrogenic overdose.
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